Cancer and Development ( Volume 94 )

Publication series :Volume 94

Author: Dyer   Michael  

Publisher: Elsevier Science‎

Publication year: 2011

E-ISBN: 9780123809179

P-ISBN(Paperback): 9780123809162

P-ISBN(Hardback):  9780123809162

Subject: Q2 Cytobiology;Q81 Bioengineering ( Biotechnology );R73 Oncology

Language: ENG

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Description

In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis. These discoveries provide important avenues for innovative new approaches to treating some of the most challenging developmental tumors.

  • Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area
  • There are now a large number of molecular targeted therapies for the treatment of cancer. Many of these therapies target pathways that are essential for normal development. Therefore, this volume provides an up-to-date and timely perspective on those pathways and biological processes that hold the greatest promise for targeted intervention.

Chapter

Front Cover

pp.:  1 – 4

Copyright

pp.:  5 – 6

Contents

pp.:  6 – 10

Contributors

pp.:  10 – 14

Preface

pp.:  14 – 16

Chapter 2: Stem Cells in Brain Tumor Development

pp.:  30 – 60

Chapter 3: MDM2 and MDMX in Cancer and Development

pp.:  60 – 92

Chapter 4: The Connections Between Neural Crest Development and Neuroblastoma

pp.:  92 – 144

Chapter 5: RB1, Development, and Cancer

pp.:  144 – 186

Chapter 6: Genetic Alterations Targeting Lymphoid Development in Acute Lymphoblastic Leukemia

pp.:  186 – 212

Chapter 7: Myogenesis and Rhabdomyosarcoma: The Jekyll and Hyde of Skeletal Muscle

pp.:  212 – 250

Chapter 8: Cerebellum: Development and Medulloblastoma

pp.:  250 – 298

Chapter 9: Rethinking Pediatric Gliomas as Developmental Brain Abnormalities

pp.:  298 – 324

Chapter 10: Tumor Macrophages: Protective and Pathogenic Roles in Cancer Development

pp.:  324 – 344

Index

pp.:  344 – 350

Contents of Previous Volumes

pp.:  350 – 386

Color Plates

pp.:  386 – 398

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