Osteoimmunology :Interactions of the Immune and Skeletal Systems

Publication subTitle :Interactions of the Immune and Skeletal Systems

Author: Lorenzo   Joseph;Horowitz   Mark;Choi   Yongwon  

Publisher: Elsevier Science‎

Publication year: 2010

E-ISBN: 9780123756718

P-ISBN(Paperback): 9780123756701

P-ISBN(Hardback):  9780123756701

Subject: R392 medical immunology;R58 Endocrine disease and metabolic disease;R62 The orthopedic surgery (surgery) to repair

Language: ENG

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Description

Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated.
The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.

  • Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work

  • Experts in bone biology and immunology (from all areas of academic and me

Chapter

Front Cover

pp.:  1 – 4

Copyright

pp.:  5 – 6

Contents

pp.:  6 – 8

Contributors

pp.:  8 – 12

Foreword

pp.:  12 – 14

Preface

pp.:  14 – 16

Chapter 3 The Adaptive Immune Response

pp.:  58 – 96

Chapter 4 The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche

pp.:  96 – 116

Chapter 5 Osteoblasts and their Signaling Pathways: New Frontiers for Linkage to the Immune System

pp.:  116 – 156

Chapter 6 The Osteoclast: The Pioneer of Osteoimmunology

pp.:  156 – 202

Chapter 7 The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

pp.:  202 – 242

Chapter 8 Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone

pp.:  242 – 284

Chapter 9 The Role of the Immune System in the Development of Osteoporosis

pp.:  284 – 316

Chapter 10 The Role of the Immune System in the Bone Loss of Inflammatory Arthritis

pp.:  316 – 340

Chapter 11 Inflammatory Bowel Disease and Bone

pp.:  340 – 358

Chapter 12 The Role of the Immune System in Fracture Healing

pp.:  358 – 384

Chapter 13 The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

pp.:  384 – 406

Chapter 14 The Role of the Immune System in Hematologic Malignancies that Affect Bone

pp.:  406 – 426

Chapter 15 Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

pp.:  426 – 458

Index

pp.:  458 – 470

Color Plates

pp.:  470 – 490

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