Progress in Medicinal Chemistry ( Volume 30 )

Publication series :Volume 30

Author: Ellis   G. P.;Luscombe   D. K.  

Publisher: Elsevier Science‎

Publication year: 1993

E-ISBN: 9780080862781

P-ISBN(Paperback): 9780444899897

P-ISBN(Hardback):  9780444899897

Subject: R9 Pharmacy

Language: ENG

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Description

In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.

Chapter

Cover

pp.:  1 – 5

Copyright Page

pp.:  5 – 6

Preface

pp.:  6 – 8

TOC$Contents

pp.:  8 – 10

CH$Chapter 2. Semi-synthetic Derivatives of Erythromycin

pp.:  66 – 98

CH$Chapter 3. Biological Significance of Manganese in Mammalian Systems

pp.:  98 – 144

CH$Chapter 4. Approach to the Chemotopography of the Digitalis Recognition Matrix in Na+/K+-transporting ATPase as a Step in the Rational Design of New Inotropic Steroids

pp.:  144 – 212

CH$Chapter 5. Amidines and Guanidines in Medicinal Chemistry

pp.:  212 – 336

CH$Chapter 6. Inhibitors of Enkephalin-degrading Enzymes as Potential Therapeutic Agents

pp.:  336 – 388

IDX$Subject Index

pp.:  388 – 398

Author Index (Vols. 1–30)

pp.:  398 – 402

Subject Index (Vols. 1–30)

pp.:  402 – 406

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