Progress in Medicinal Chemistry ( Volume 46 )

Publication series ：Volume 46

Author： Lawton   G.;Witty   David R.  

Publisher： Elsevier Science‎

Publication year： 2011

E-ISBN: 9780080569680

P-ISBN(Paperback): 9780444530189

P-ISBN(Hardback):  9780444530189

Subject： R313 Medical Chemistry

Language： ENG

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Description

Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging:
* HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)
* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)
* Nicotinic a7 choline receptor (agonists and positive allosteric modulators).
* Bradykinin receptor (new approach to pain therapy)
* Histone deacetylase (new drugs for cancer)
* 5-HT2c receptor modulators (various CNS indications)

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect

Chapter

Cover

pp.：  1 – 6

Preface

pp.：  6 – 8

Contents

pp.：  8 – 10

List of Contributors

pp.：  10 – 12

1 The Discovery of Raltegravir, an Integrase Inhibitor for the Treatment of HIV Infection

pp.：  12 – 40

2 Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1

pp.：  40 – 142

3 alpha7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators

pp.：  142 – 184

4 Small Molecule Bradykinin B1 Receptor Antagonists as Potential Therapeutic Agents for Pain

pp.：  184 – 216

5 Histone Deacetylase Inhibitors: A Novel Class of Anti-Cancer Agents on its Way to the Market

pp.：  216 – 292

6 5-HT2C Ligands: Recent Progress

pp.：  292 – 402

Subject Index

pp.：  402 – 406

Cumulative Index of Authors for Volumes 1- 46

pp.：  406 – 411

Cumulative Author Index

pp.：  411 – 420

Color Plate

pp.：  420 – 422

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