Computational Neuroscience in Epilepsy

Author: Soltesz   Ivan;Staley   Kevin  

Publisher: Elsevier Science‎

Publication year: 2011

E-ISBN: 9780080559537

P-ISBN(Paperback): 9780123736499

P-ISBN(Hardback):  9780123736499

Subject: R742.1 epilepsy

Language: ENG

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Description

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.

  • Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures
  • Contributors are top experts at the forefront of computational epilepsy research
  • Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Chapter

Cover

pp.:  1 – 6

Table of Contents

pp.:  6 – 10

Contributors

pp.:  10 – 14

Foreword

pp.:  14 – 14

Part II Epilepsy and Altered Network Topology

pp.:  108 – 162

Part III Destabilization of Neuronal Networks

pp.:  162 – 266

Part IV Homeostasis and Epilepsy

pp.:  266 – 300

Part V Mechanisms of Synchronization

pp.:  300 – 354

Part VI Interictal to Ictal Transitions

pp.:  354 – 476

Part VII Seizure Dynamics

pp.:  476 – 534

Part VIII Towards Computer-Aided Therapy

pp.:  534 – 608

Index

pp.:  608 – 626

Color Plates

pp.:  626 – 650

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