Cancer Drug Design and Discovery

Author: Neidle   Stephen  

Publisher: Elsevier Science‎

Publication year: 2011

E-ISBN: 9780080554952

P-ISBN(Paperback): 9780123694485

P-ISBN(Hardback):  9780123694485

Subject: R979.1 anti - tumor, anti - cancer drug

Language: ENG

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Description

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options.

* Covers both currently available drugs as well as those under development
* Provides a clinical perspective on trials of new anticancer agents
* Presents drug discovery examples through the use of case histories

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Contents

pp.:  6 – 11

About the editor

pp.:  11 – 12

Contributors

pp.:  12 – 15

Introduction

pp.:  15 – 18

PART I: BASIC PRINCIPLES

pp.:  18 – 106

PART II: METHODOLOGY

pp.:  106 – 172

PART III: DRUGS IN THE CLINIC

pp.:  172 – 244

PART IV: NEW AGENTS

pp.:  244 – 420

PART V: THE REALITY OF CANCER DRUGS IN THE CLINIC

pp.:  420 – 453

Glossary

pp.:  453 – 457

Index

pp.:  457 – 491

Color Plates

pp.:  491 – 518

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