HIV: Molecular Biology and Pathogenesis: Viral Mechanisms ：Molecular Biology and Pathogenesis: Viral Mechanisms ( Volume 48 )

Publication subTitle ：Molecular Biology and Pathogenesis: Viral Mechanisms

Publication series ：Volume 48

Author： August   J. Thomas;Murad   Ferid;Jeang   Kuan-Teh  

Publisher： Elsevier Science‎

Publication year： 2000

E-ISBN: 9780080553924

P-ISBN(Paperback): 9780120329496

P-ISBN(Hardback):  9780120329496

Subject： R512.91 AIDS Acquired immune deficiency syndrome (AIDS)

Language： ENG

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.
The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

  • Detailed insights into viral packaging, expression, and assembly
  • Mechanistic understanding of how HIV interacts with receptors and infects cells
  • Delineation of virally encoded regulatory processes unique to HIV
  • Clinical Applications:
    • An updated review of current chemotherapeutics for HIV
    • New concepts in the discovery and design of novel anti-HIV drugs
    • The latest developments in HIV-vaccine research

Chapter

Front Cover

pp.：  1 – 4

HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms

pp.：  4 – 5

Copyright Page

pp.：  5 – 6

Contents

pp.：  6 – 14

Contributors

pp.：  14 – 18

Preface

pp.：  18 – 22

Chapter 1. HIV RNA Packaging and Lentivirus-Based Vectors

pp.：  22 – 50

Chapter 2. Multiple Biological Roles Associated with the Repeat (R) Region of the HIV-1 RNA Genome

pp.：  50 – 96

Chapter 3. HIV Accessory Proteins: Multifunctional Components of a Complex System

pp.：  96 – 142

Chapter 4. Role of Chromatin in HIV-1 Transcriptional Regulation

pp.：  142 – 182

Chapter 5. NF-κB and HIV: Linking Viral and Immune Activation

pp.：  182 – 230

Chapter 6. Tat as a Transcriptional Activator and a Potential Therapeutic Target for HIV-1

pp.：  230 – 250

Chapter 7. From the Outside In: Extracellular Activities of HIV Tat

pp.：  250 – 272

Chapter 8. Rev Protein and Its Cellular Partners

pp.：  272 – 320

Chapter 9. HIV-1 Nef: A Critical Factor in Viral-Induced Pathogenesis

pp.：  320 – 366

Chapter 10. Nucleocapsid Protein of Human Immunodeficiency Virus as a Model Protein with Chaperoning Functions and as a Target for Antiviral Drugs

pp.：  366 – 394

Chapter 11. Bioactive CD4 Ligands as Pre- and/or Postbinding Inhibitors of HIV-1

pp.：  394 – 430

Chapter 12. Coreceptors for Human Immunodeficiency Virus and Simian Immunode.ciency Virus

pp.：  430 – 500

Index

pp.：  500 – 512

Contents of Previous Volumes

pp.：  512 – 524

The users who browse this book also browse


No browse record.