HIV I: Molecular Biology and Pathogenesis: Clinical Applications ：Molecular Biology and Pathogenesis: Clinical Applications ( Volume 49 )

Publication subTitle ：Molecular Biology and Pathogenesis: Clinical Applications

Publication series ：Volume 49

Author： August   J. Thomas;Murad   Ferid;Jeang   Kuan-Teh  

Publisher： Elsevier Science‎

Publication year： 2000

E-ISBN: 9780080549866

P-ISBN(Paperback): 9780120329502

P-ISBN(Hardback):  9780120329502

Subject： R512.91 AIDS Acquired immune deficiency syndrome (AIDS)

Language： ENG

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.
The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

  • Detailed insights into viral packaging, expression, and assembly
  • Mechanistic understanding of how HIV interacts with receptors and infects cells
  • Delineation of virally encoded regulatory processes unique to HIV
  • Clinical Applications:
    • An updated review of current chemotherapeutics for HIV
    • New concepts in the discovery and design of novel anti-HIV drugs
    • The latest developments in HIV-vaccine research

Chapter

Front Cover

pp.：  1 – 4

HIV-1: MOLECULAR BIOLOGY AND PATHOGENESIS

pp.：  4 – 5

Copyright Page

pp.：  5 – 6

Contents

pp.：  6 – 16

Contributors

pp.：  16 – 20

Preface

pp.：  20 – 24

Chapter 1. HIV Therapeutics: Past, Present, and Future

pp.：  24 – 64

Chapter 2. HIV Drug Resistance and Viral Fitness

pp.：  64 – 90

Chapter 3. Inhibitors of HIV-1 Reverse Transcriptase

pp.：  90 – 134

Chapter 4. HIV-1 Protease: Maturation, Enzyme Specificity, and Drug Resistance

pp.：  134 – 170

Chapter 5. HIV-1 Integrase Inhibitors: Past, Present, and Future

pp.：  170 – 190

Chapter 6. Selection of HIV Replication Inhibitors: Chemistry and Biology

pp.：  190 – 222

Chapter 7. Therapies Directed against the Rev Axis of HIV Autoregulation

pp.：  222 – 252

Chapter 8. HIV-1 Gene Therapy: Promise for the Future

pp.：  252 – 286

Chapter 9. Assessment of HIV Vaccine Development: Past, Present, and Future

pp.：  286 – 338

Chapter 10. HIV-1-Associated Central Nervous System Dysfunction

pp.：  338 – 410

Chapter 11. Molecular Mechanisms of Human Immunodeficiency Virus Type 1 Mother–Infant Transmission

pp.：  410 – 440

Chapter 12. Molecular Epidemiology of HIV-1: An Example of Asia

pp.：  440 – 460

Chapter 13. Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment, and Prevention

pp.：  460 – 502

Chapter 14. Animal Models for AIDS Pathogenesis

pp.：  502 – 538

Index

pp.：  538 – 550

Contents of Previous Volumes

pp.：  550 – 562

The users who browse this book also browse