Basic Biology and Clinical Impact of Immunosenescence ( Volume 13 )

Publication series ：Volume 13

Author： Pawelec   G.  

Publisher： Elsevier Science‎

Publication year： 2003

E-ISBN: 9780080546483

P-ISBN(Paperback): 9780444513168

P-ISBN(Hardback):  9780444513168

Subject： Q2 Cytobiology;R392 medical immunology;R592 geriatrics

Language： ENG

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.


Chapter

Cover

pp.：  1 – 6

Table of Contents

pp.：  6 – 8

Preface

pp.：  8 – 12

Chapter 1. The OCTO and NONA Immune Longitudinal Studies: A Review of 11 years Studies of Swedish very old humans

pp.：  12 – 28

Chapter 2. Immune Measures which Predict 9-Year Survival in an Elderly Population Sample

pp.：  28 – 40

Chapter 3. Immunological and Immunogenetic Markers of Successful and Unsuccessful Ageing

pp.：  40 – 58

Chapter 4. Developmental Aspects of the Thymus in Aging

pp.：  58 – 90

Chapter 5. Effective Immunity During Late Life; A Possible Role for the Thymus

pp.：  90 – 104

Chapter 6. Alterations in Signal Transduction in T Lymphocytes and Neutrophils with Ageing

pp.：  104 – 134

Chapter 7. CD28 Downregulation and Expression of NK-Associated Receptors on T Cells in Aging and Situations of Chronic Activation of the Immune System

pp.：  134 – 144

Chapter 8. Characterisation of NK Cells in the Elderly

pp.：  144 – 170

Chapter 9. T Cell Ageing and Immune Surveillance

pp.：  170 – 184

Chapter 10. A Road to Ruins: An Insight Into Immunosenescence

pp.：  184 – 202

Chapter 11. Genetic Damage and Ageing T Cells

pp.：  202 – 228

Chapter 12. Role of DNA-dependent Protein Kinase (DNA-PK), A Protein with Multiple Intracellular Functions, in Cells of the Ageing Immune System

pp.：  228 – 242

Chapter 13. Linker Histone H1o Gene Expression During Ageing and After the Effect of Histone Deacetylase Inhibitors in Human Diploid Fibroblasts and T Lymphocytes

pp.：  242 – 254

Chapter 14. Zinc and the Immune System of Elderly

pp.：  254 – 272

Chapter 15. Altered Zinc Binding by Metallothioneins in Immune-Neuroendocrine Senescence: A Vicious Circle Between Metallothioneins and Chaperones?

pp.：  272 – 294

Chapter 16. T Cell Exhaustion and Aging: Is Replicative Senescence Relevant?

pp.：  294 – 306

Chapter 17. Cultured T cell Clones as Models for Immunosenescence

pp.：  306 – 320

Contributor Addresses

pp.：  320 – 324

The users who browse this book also browse