Description
Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells.
Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers.
This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.
Chapter
Acknowledgments
pp.：
28 – 30
Chapter 1. Herpes Simplex Virus as a Gene-Delivery Vector for the Central Nervous System
pp.：
30 – 54
Chapter 2. Biology of Herpes Simplex Virus (HSV) Defective Viruses and Development of the Amplicon System
pp.：
54 – 72
Chapter 3. Group C Adenoviruses as Vectors for Gene Therapy
pp.：
72 – 84
Chapter 4. Genetics and Biology of Adeno-Associated Virus
pp.：
84 – 104
Chapter 5. Genetics and Biology of Retroviral Vectors
pp.：
104 – 118
Chapter 6. HSV Vectors in the Mammalian Brain: Molecular Analysis of Neuronal Physiology, Generation of Genetic Models, and Gene Therapy of Neurological Disorders
pp.：
118 – 138
Chapter 7. The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System
pp.：
138 – 148
Chapter 8. Viral Vector-Mediated Gene Transfer in the Nervous System: Application to the Reconstruction of Neural Circuits in the Injured Mammalian Brain
pp.：
148 – 162
Chapter 9. The Use of Herpes Simplex Virus Vectors for Protection from Necrotic Neuron Death
pp.：
162 – 186
Chapter 10. In Viva Promoter Analysis in the Adult Central Nervous System Using Viral Vectors
pp.：
186 – 202
Chapter 11. Adenoviral-Mediated Gene Transfer: Potential Therapeutic Applications
pp.：
202 – 222
Chapter 12. Transfer and Expression of Potentially Therapeutic Genes into the Mammalian Central Nervous System in Viva Using Adeno-Associated Viral Vectors
pp.：
222 – 240
Chapter 13. Genetic Modification of Cells with Retrovirus Vectors for Grafting into the Central Nervous System
pp.：
240 – 268
Chapter 14. Virus Vector-Mediated Transfer of Drug-Sensitivity Genes for Experimental Brain Tumor Therapy
pp.：
268 – 288
Chapter 15. Brain Tumor Therapy Using Genetically Engineered Replication-Competent Virus
pp.：
288 – 304
Chapter 16. Transfer and Expression of Antioncogenes and Paraneoplastic Genes in Normal and Neoplastic Cells in Vitro and in Viva
pp.：
304 – 322
Chapter 17. Transneuronal Tracing with Alpha-herpesviruses: A Review of the Methodology
pp.：
322 – 348
Chapter 18. Pseudorabies Virus Replication and Assembly in the Rodent Central Nervous System
pp.：
348 – 378
Chapter 19. Pseudorabies Virus: A Transneuronal Tracer for Neuroanatomical Studies
pp.：
378 – 396
Chapter 20. Molecular Properties of Alphaherpesviruses Used in Transneuronal Pathway Tracing
pp.：
396 – 424
Chapter 21. Molecular Analysis of Rabies and Pseudorabies Neurotropism
pp.：
424 – 440
Chapter 22. The Use of Retroviral Vectors in the Study of Cell Lineage and Migration during the Development of the Mammalian Central Nervous System
pp.：
440 – 464
Chapter 23. Retroviral Vectors for the Study of Neuroembryology: Immortalization of Neural Cells
pp.：
464 – 506
Color Plate Section
pp.：
516 – 526
Viral Vectors
：Gene Therapy and Neuroscience Applications
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
