Description
Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs.
This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.
Chapter
Chapter 2. Cholinergic receptors and neurodegenerative diseases
pp.：
16 – 22
Chapter 3. Nicotinic systems in central nervous systems disease: degenerative disorders and beyond
pp.：
22 – 34
Chapter 4. Central nicotinic receptor ligands and pharmacophores
pp.：
34 – 46
Chapter 5. Structural aspects of high affinity ligands for the α4β2 neuronal nicotinic receptor
pp.：
46 – 56
Chapter 6. Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist
pp.：
56 – 62
Chapter 7. Receptors in neurodegenerative diseases, muscarinic cholinergic receptors
pp.：
62 – 66
Chapter 8. Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors
pp.：
66 – 72
Chapter 9. CI-1017, a functionally Ml-selective muscarinic agonist: design, synthesis, and preclinical pharmacology
pp.：
72 – 80
Chapter 10. Ligands for the common allosteric site of acetylcholine M2-receptors: development and application
pp.：
80 – 88
Chapter 11. Receptors in cardiovascular disease: review and introduction
pp.：
88 – 94
Chapter 12. Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics
pp.：
94 – 104
Chapter 13. The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action
pp.：
104 – 112
Chapter 14. α1-Adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety
pp.：
112 – 122
Chapter 15. Selection, design and evaluation of new radioligands for PET studies of cardiac adrenoceptors
pp.：
122 – 132
Chapter 16. Enigmatic receptors
pp.：
132 – 136
Chapter 17. Imidazoline receptors: a challenge
pp.：
136 – 142
Chapter 18. Sigma receptors: recent advances and new clinical potentials
pp.：
142 – 150
Chapter 19. Excitatory amino acid receptors
pp.：
150 – 152
Chapter 20. Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications
pp.：
152 – 162
Chapter 21. Metabotropic glutamate receptors: a structural view point
pp.：
162 – 170
Chapter 22. Synthesis and pharmacological properties of novel glycine antagonists
pp.：
170 – 178
Chapter 23. Receptors in neurodegenerative diseases
pp.：
178 – 184
Chapter 24. Neurotrophin receptor structure and interactions
pp.：
184 – 192
Chapter 25. The RET receptor tyrosine kinase: activation, signalling and significance in neural development and disease
pp.：
192 – 196
Chapter 26. The ciliary neurotrophic factor and its receptor, CNTFRα
pp.：
196 – 204
Chapter 27. Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke
pp.：
204 – 212
Chapter 28. Apoptosis induced by death receptors
pp.：
212 – 218
Chapter 29. Hijacked receptors
pp.：
218 – 222
Chapter 30. ICAM-1 receptors and cold viruses
pp.：
222 – 230
Chapter 31. Viral-encoded G-protein coupled receptors: new targets for drug research?
pp.：
230 – 236
Chapter 32. Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines
pp.：
236 – 244
Chapter 33. General topics and perspectives
pp.：
244 – 246
Chapter 34. Pharmacological evidence of muscarinic receptor heterodimerization
pp.：
246 – 258
Chapter 35. Constitutive activity of G protein coupled receptors and drug action
pp.：
258 – 264
Chapter 36. New dimensions in G protein signalling: Gβ5 and the RGS proteins
pp.：
264 – 268
Chapter 37. Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse
pp.：
268 – 276
Author Index
pp.：
276 – 278
Keyword Index
pp.：
278 – 282
Receptor Chemistry Towards the Third Millennium
( Volume 31 )
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