Recent Advances in Nucleosides: Chemistry and Chemotherapy ：Chemistry and Chemotherapy

Publication subTitle ：Chemistry and Chemotherapy

Author： Chu C. K.

Publisher： Elsevier Science‎

Publication year： 2002

E-ISBN: 9780080540368

P-ISBN(Paperback): 9780444509512

P-ISBN(Hardback): 9780444509512

Subject： Q525 nucleoside

Language： ENG

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Description

The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

Chapter

Front Cover

pp.： 1 – 4

Recent Advances in Nucleosides: Chemistry and Chemotherapy

pp.： 4 – 5

pp.： 5 – 6

Contents

pp.： 6 – 10

Preface

pp.： 10 – 12

Chapter 1. Mission oriented research: An experience in Dr. Jack J. Fox's laboratory

pp.： 12 – 32

Chapter 2. Development of new radical reactions with a vinylsilyl group and their application to the synthesis of branched-chain sugar nucleosides

pp.： 32 – 68

Chapter 3. Synthesis of purine acyclonucleosides via ribofuranose-ring cleavage of purine nucleosides by diisobutylaluminum hydride

pp.： 68 – 82

Chapter 4. The chemistry of nucleoside and dinucleotide inhibitors of nosine monophosphate dehydrogenase (IMPDH)

pp.： 82 – 102

Chapter 5. Nucleoside and nucleotide prodrugs

pp.： 102 – 160

Chapter 6. Antiviral Isonucleosides: discovery, chemisry and chemical biology

pp.： 160 – 178

Chapter 7. Synthesis and biological activity of isopolar acyclic nucleotide analogs

pp.： 178 – 250

Chapter 8. Synthesis of pyranose nucleosides and related nucleosides with a six-membered carbohydrate mimic

pp.： 250 – 302

Chapter 9. 5'-Norcarbanucleosides in L-like configurations

pp.： 302 – 310

Chapter 10. Tricyclic nucleosides revisited

pp.： 310 – 338

Chapter 11. Unusual analogues of nucleosides: chemistry and biological activity

pp.： 338 – 370

Chapter 12. Lithiation-based silylation and stannylation for nucleoside synthesis

pp.： 370 – 388

Chapter 13. Purine metabolism in parasites: potential targets for chemotherapy

pp.： 388 – 428

Chapter 14. Antiviral β-L-nucleosides specific for hepatits B virus infection

pp.： 428 – 444

Chapter 15. Antiviral activity of nucleoside analogues: the BVDU connection

pp.： 444 – 466

Chapter 16. The role of the cellular deoxynucleoside kinases in activation of nucleoside analogs used in chemotherapy

pp.： 466 – 488

Chapter 17. Cellular transport of nucleotide analogs

pp.： 488 – 516

Chapter 18. 5-Aza-7-deazapurines: synthesis and properties of nucleosides and oligonucleotides

pp.： 516 – 546

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