Extracellular Matrix and The Liver ：Approach to Gene Therapy

Publication subTitle ：Approach to Gene Therapy

Author： Okazaki   Isao;Ninomiya   Yosifumi;Kyuichi   Tanikawa  

Publisher： Elsevier Science‎

Publication year： 2003

E-ISBN: 9780080531502

P-ISBN(Paperback): 9780125252515

P-ISBN(Hardback):  9780125252515

Subject： Q2 Cytobiology;Q3 Genetics;Q7 Molecular Biology;R73 Oncology

Language： ENG

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Description

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches.

The chapters are divided into six sections as follows:

  • Basic Science of Extracellular Matrix
  • Cells Responsible for Extracellular Matrix Production
  • Activation Mechanism of Hepatic Cells and Signal Transduction
  • Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
  • Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
  • New Strategies for the treatment of Liver Cirrhosis
  • Discusses the possibility of gene therapy for liver cirrhosis
  • Includes information on new aspects of hepatic stellate cells
  • Written by top experts in basic science and clinical hepatology

Chapter

Front Cover

pp.：  1 – 4

Extracellular Matrix and the Liver

pp.：  4 – 5

Copyright Page

pp.：  5 – 6

Contents

pp.：  6 – 16

Contributors

pp.：  16 – 22

Preface

pp.：  22 – 24

PART I: Basic Science of Extracellular Matrix

pp.：  24 – 110

PART II: Cells Responsible for Extracellular Matrix Production

pp.：  110 – 176

PART III: Activation Mechanism of Hepatic Stellate Cells and Signal Transduction

pp.：  176 – 272

PART IV: Basic Science of Matrix Metalloproteinases and Tissue Inhibitor Metalloproteinases

pp.：  272 – 354

PART V: Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Liver Fibrosis

pp.：  354 – 412

PART VI: New Strategies for the Treatment of Liver Cirrhosis

pp.：  412 – 478

Index

pp.：  478 – 492

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