Description
This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. This book includes up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or fluorocarbon-based blood substitutes, and covers issues of hemoglobin toxicity and side effects such as vasoconstriction in more detail using carefully designed in vivo and ex vivo techniques. This book is also a collection of various new types of red cell substitutes such as recombinant Hbs, recombinant albumine-lipidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering.
Chapter
Chapter 2. The Role of Blood Substitutes in Emerging Healthcare Systems
pp.：
34 – 52
Chapter 3. Red Cell Substitutes: Evolution of Approaches for Demonstrating Efficacy
pp.：
52 – 60
Chapter 4. The Clinical Utility of Human Polymerized Hemoglobins as a Blood Substitute Following Acute Trauma and Urgent Surgery
pp.：
60 – 74
Chapter 5. Recent Progress in the Development of Recombinant Human Hemoglobin (rHbl.1) as an Oxygen Therapeutic
pp.：
74 – 94
Chapter 6. Overview of the Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on Oxygenation, Perfusion of the Microcirculation, and Clinical Studies
pp.：
94 – 110
Chapter 7. Update on Perfluorocarbon-Based Oxygen Delivery Systems
pp.：
110 – 122
Chapter 8. Red Cell Substitutes: Past Problems, Current Dilemmas
pp.：
122 – 130
Chapter 9. Round Table Discussion: "The Target and Assessment of Clinical Tests"
pp.：
130 – 144
Chapter 10. Biophysical Criteria for Microcirculatory Efficacy of Blood Substitutes
pp.：
144 – 154
Chapter 11. Experimental and Mathematical Simulation of Oxygen Transport by Hemoglobin-based Blood Substitute
pp.：
154 – 166
Chapter 12. Tissue Oxygen Delivery and Tissue Distribution of Liposome Encapsulated Hemoglobin
pp.：
166 – 180
Chapter 13. Polymeric Biodegradable Hemoglobin Nanocapsule as a New Red Blood Cell Substitute
pp.：
180 – 190
Chapter 14. Evaluation of the Oxygen Transporting Capability of Hemoglobin Vesicles
pp.：
190 – 204
Chapter 15. Microvascular Responses to Hemodilution with Hb-Vesicles: Importance of Resistance Arteries and Mechanisms of Vasoconstriction
pp.：
204 – 220
Chapter 16. Hemoglobin-based Blood Substitutes and Mechanisms of Toxicity
pp.：
220 – 230
Chapter 17. in vivo Oxygenation of Deoxy-Hemolink™ Following Exchange Transfusions of 50% or 90% the Blood Volume in Rats
pp.：
230 – 244
Chapter 18. Safety and Efficacy of Hemoglobin Modified by Cross-linking or Polymerization
pp.：
244 – 260
Chapter 19. The Heme Oxygenase System In Liver Microcirculation: A Key Mechanism for Hemoglobin Degradation
pp.：
260 – 270
Chapter 20. Vascular Activities of Hemoglobin-Based Oxygen Carriers
pp.：
270 – 284
Chapter 21. Zero-link Polymerization: a New Class of Polymeric Hemoglobins
pp.：
284 – 300
Chapter 22. Recombinant Hemoglobins with Low Oxygen Affinity and High Cooperativity
pp.：
300 – 316
Chapter 23. Properties of Poly(ethylene glycol)-conjugated Red Blood Cells
pp.：
316 – 334
Chapter 24. Oxygen-Transport Albumin: A New Hemoprotein Incorporating Lipidheme as a Red Cell Substitute
pp.：
334 – 346
Chapter 25. Fluorocarbon Emulsions as Blood Substitutes
pp.：
346 – 358
Chapter 26. Heparin-like New Molecules with Blood
pp.：
358 – 378
Chapter 27. Recent Developments and Future Perspectives for Preserved Platelets and Platelet Substitutes
pp.：
378 – 392
Chapter 28. Development and Clinical Implications of Platelet Substitutes
pp.：
392 – 402
Chapter 29. Impact on the Appearance of Blood Substitutes Replacing Blood in Transfusion Medicine
pp.：
402 – 410
Blood Substitutes, Present and Future Perspectives
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