Acute Toxicology Testing ( 2 )

Publication series ：2

Author： Gad Shayne C.;Chengelis Christopher P.

Publisher： Elsevier Science‎

Publication year： 1997

E-ISBN: 9780080525921

P-ISBN(Paperback): 9780122722509

P-ISBN(Hardback): 9780122722509

Subject： R99 Toxicology (Toxicology)

Language： ENG

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Description

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.

Key Features
* Over 100 tables summarizing and interpreting results
* Complete coverage of all major test designs and their limitations and advantages
* Current status of alternative test designs and models

Chapter

Front Cover

pp.： 1 – 5

Acute Toxicology Testing

pp.： 5 – 6

pp.： 6 – 8

Contents

pp.： 8 – 16

Preface to the First Edition

pp.： 16 – 18

Preface to the Second Edition

pp.： 18 – 20

Chapter 1. Introduction

pp.： 20 – 36

Chapter 2. Acute Toxicology Program: Study Design and Development

pp.： 36 – 50

Chapter 3. Tests for Dermal Irritation and Corrosion

pp.： 50 – 76

Chapter 4. Ocular Irritation Testing

pp.： 76 – 104

Chapter 5. Dermal Sensitization

pp.： 104 – 146

Chapter 6. Photosensitization and Phototoxicity

pp.： 146 – 174

Chapter 7. Lethality Testing

pp.： 174 – 216

Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes

pp.： 216 – 240

Chapter 9. Systemic Acute Toxicity Testing

pp.： 240 – 276

Chapter 10. Routes, Formulations, and Vehicles

pp.： 276 – 324

Chapter 11. Considerations Specific to Animal Test Models

pp.： 324 – 380

Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies

pp.： 380 – 422

Chapter 13. Acute Inhalation

pp.： 422 – 486

Chapter 14. Problems and Issues

pp.： 486 – 512

Appendix A. Common Regulatory and Toxicological Acronyms

pp.： 512 – 514

Appendix B. Table for Calculation of Median Effective Dose By Moving Average

pp.： 514 – 536

Appendix C. Vehicles

pp.： 536 – 544

Appendix D. Definitions of Terms and Lexicon of Clinical Observations

pp.： 544 – 548

Index

pp.： 548 – 554

Color Plate Section

pp.： 554 – 562

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