Analytical Determination of Nicotine and Related Compounds and their Metabolites

Author: Gorrod   J. W.;Jacob   P.   III  

Publisher: Elsevier Science‎

Publication year: 1999

E-ISBN: 9780080525518

P-ISBN(Paperback): 9780444500953

P-ISBN(Hardback):  9780444500953

Subject: O65 Analytical Chemistry

Language: ENG

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Description

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Foreword

pp.:  6 – 10

List of Contributors

pp.:  10 – 14

Contents

pp.:  14 – 16

Chapter 3. Biotransformation of Nicotine in Mammalian Systems

pp.:  60 – 84

Chapter 4. Chemical Properties of Nicotine and Other Tobacco-Related Compounds

pp.:  84 – 164

Chapter 5. The Physical Chemistry of Nicotine

pp.:  164 – 206

Chapter 6. Use of Gas Chromatographic and Mass Spectrometric Techniques for the Determination of Nicotine and its Metabolites

pp.:  206 – 240

Chapter 7. Use of High-Performance Liquid Chromatographic-Mass Spectrometric (LC-MS) Techniques for the Determination of Nicotine and its Metabolites

pp.:  240 – 280

Chapter 8. Use of Immunoassay Techniques for the Determination of Nicotine and its Metabolites

pp.:  280 – 300

Chapter 9. Determination of Nicotine in Tobacco, Tobacco Processing Environments and Tobacco Products

pp.:  300 – 408

Chapter 10. Determination of Nicotine in Pharmaceutical Products and Dietary Sources

pp.:  408 – 436

Chapter 11. Nitrosamines Derived from Nicotine and Other Tobacco Alkaloids

pp.:  436 – 504

Chapter 12. Determination of Nicotine in Mainstream and Sidestream Cigarette Smoke

pp.:  504 – 546

Chapter 13. Nicotine in Environmental Tobacco Smoke

pp.:  546 – 598

Chapter 14. Determination of Nicotine and its Metabolites in Biological Fluids: in vivo Studies

pp.:  598 – 660

Chapter 15. Determination of Nicotine and its Metabolites in Biological Fluids: in vitro Studies

pp.:  660 – 684

Chapter 16. Uses and Abuses of Cotinine as a Marker of Tobacco Smoke Exposure

pp.:  684 – 736

Subject Index

pp.:  736 – 774

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