Biomedical Applications of Microprobe Analysis

Author: Ingram   Peter;Shelburne   John D.;Roggli   Victor L.  

Publisher: Elsevier Science‎

Publication year: 1999

E-ISBN: 9780080524566

P-ISBN(Paperback): 9780123710208

P-ISBN(Hardback):  9780123710208

Subject: R318.51 light, Laser Biomedicine

Language: ENG

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Description

Biomedical Applications of Microprobe Analysis is a combination reference/laboratory manual for the use of microprobe analysis in both clinical diagnostic and research settings. Also called microchemical microscopy, microprobe analysis uses high-energy bombardment of cells and tissue, in combination with high resolution EM or confocal microscopy to provide a profile of the ion, metal, and mineral concentrations present in a sample. This allows insight into the physiology and pathophysiology of a wide variety of cells and tissues.
This book describes methods for obtaining detailed information about the identity and composition of particles too small to be seen with the naked eye and describes how this information can be useful in diagnostic and biomedical research.

  • Up-to-date review of electron microprobe analysis
  • Detailed descriptions of sample preparation techniques
  • Recent technologies including confocal microscopy, infrared microspectroscopy, and laser raman spectroscopy
  • Over 100 illustrations with numerous specific applications
  • Contributions by world-renowned experts in the field
  • Brief summary of highlights precedes each chapter

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

CONTENTS

pp.:  6 – 10

PREFACE

pp.:  10 – 14

CONTRIBUTORS

pp.:  14 – 18

SYNOPSES OF CHAPTERS

pp.:  18 – 28

Chapter 2. Preparatory Techniques, Including Cryotechnology

pp.:  86 – 114

Chapter 3. Overview of Applications in Medicine

pp.:  114 – 150

Chapter 4. Diagnostic Applications of Confocal Microscopy

pp.:  150 – 176

Chapter 5. Light Microscopical Analytical Techniques

pp.:  176 – 228

Chapter 6. Microprobe Analysis in Pulmonary Pathology

pp.:  228 – 284

Chapter 7. Microprobe Analysis in Forensic Medicine

pp.:  284 – 300

Chapter 8. Principles of Tissue Preparation for High-Resolution Quantitative X-ray Microanalysis: Retaining the Quasi in vivo Geometry and Elemental Distribution in Muscle Cells

pp.:  300 – 318

Chapter 9. Microprobe Analysis of Urinary Stones

pp.:  318 – 342

Chapter 10. X-ray Microanalytical Studies of Epithelial Cells with Reference to Cystic Fibrosis

pp.:  342 – 366

Chapter 11. Microprobe Analysis in Hepatic Metal Overload Disease States

pp.:  366 – 400

Chapter 12 X-ray Microanalysis of the Integument

pp.:  400 – 428

Chapter 13. Applications of Energy Dispersive Microprobe Analysis in Ophthalmic Pathology

pp.:  428 – 472

Chapter 14. Ionic Regulation of Proliferation in Normal and Cancer Cells

pp.:  472 – 488

Chapter 15. Secondary Ion Mass Spectrometry

pp.:  488 – 536

Chapter 16. Laser Microprobe Mass Spectrometry: Applications to Biological Specimens

pp.:  536 – 562

INDEX

pp.:  562 – 574

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