Foundations of Structural Biology

Author: Banaszak   Leonard J.  

Publisher: Elsevier Science‎

Publication year: 2000

E-ISBN: 9780080521848

P-ISBN(Paperback): 9780120777006

P-ISBN(Hardback):  9780120777006

Subject: Q617 biological structure theory

Language: ENG

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Description

Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules.

Key Features
* Explains how to use coordinate databases and atomic coordinates of biological macromolecules
* Teaches the skills of stereoviewing
* Contains computer-generated stereographics
* Describes the principles of symmetry and handedness in proteins and DNA
* Introduces metal and lipid binding proteins and DNA-protein interactions
* Explains the principles involved in understanding secondary and quaternary structure
* Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Contents

pp.:  6 – 12

Preface

pp.:  12 – 13

CHAPTER 1. Introduction to Protein Structure

pp.:  13 – 18

CHAPTER 2. Solid-State and Solution Methods for Determining Biological Macromolecular Structure

pp.:  18 – 37

CHAPTER 3. Crystallographic Coordinates and Stereodrawings

pp.:  37 – 62

CHAPTER 4. Properties of Biomacromolecules in the Crystalline State

pp.:  62 – 73

CHAPTER 5. Quaternary Structure of Proteins

pp.:  73 – 87

CHAPTER 6. Secondary Structure of Proteins

pp.:  87 – 98

CHAPTER 7. Domains and Supersecondary Structure

pp.:  98 – 111

CHAPTER 8. Conformational States in Crystal and Nuclear Magnetic Resonance Structures

pp.:  111 – 126

CHAPTER 9. Hydrogen Bonds and Water Molecules in Crystalline Proteins

pp.:  126 – 138

CHAPTER 10. Protein and Nucleic Acid Complexes

pp.:  138 – 149

CHAPTER 11. Metal Ions Bound to Proteins

pp.:  149 – 160

CHAPTER 12. Lipid–Protein Interactions

pp.:  160 – 170

APPENDIX 1: Extra Reading in Structural Biology

pp.:  170 – 172

APPENDIX 2: Macromolecular Structure Information Resources

pp.:  172 – 175

Index

pp.:  175 – 181

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