Energy Metabolism and Lifespan Determination ( Volume 14 )

Publication series ：Volume 14

Author： Mattson   M. P.  

Publisher： Elsevier Science‎

Publication year： 2003

E-ISBN: 9780080494760

P-ISBN(Paperback): 9780444514929

P-ISBN(Hardback):  9780444514929

Subject： Q5 Biochemistry;Q81 Bioengineering ( Biotechnology );R592 geriatrics

Language： ENG

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Description

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production.



During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

Chapter

Cover

pp.：  1 – 2

Energy Metabolism and Lifespan Determination

pp.：  2 – 5

Copyright Page

pp.：  5 – 6

Table of Content

pp.：  6 – 8

Preface

pp.：  8 – 10

Chapter 1. The Search for Energy: A Driving Force in Evolution and Aging

pp.：  10 – 22

Chapter 2. Insulin Signaling, Glucose Metabolism Oxidative Stress, and Aging

pp.：  22 – 44

Chapter 3. Oxidative Phosphorylation, Mitochondrial Proton Cycling, Free-radical Production and Aging

pp.：  44 – 78

Chapter 4. Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction

pp.：  78 – 96

Chapter 5. Cellular and Molecular Mechanisms Whereby Dietary Restriction Extends Healthspan: A Beneficial Type of Stress

pp.：  96 – 114

Chapter 6. Mitochondrial Oxidative Stress and Caloric Restriction

pp.：  114 – 132

Chapter 7. Understanding the Aging Fly Through Physiological Genetics

pp.：  132 – 152

Chapter 8. Metabolism and Life span Determination in C. elegans

pp.：  152 – 186

Chapter 9. Electron Transport and Life span in C. elegans

pp.：  186 – 206

Chapter 10. Cellular Glucose Sensing, Energy Metabolism, and Aging in Saccharomyces cerevisiae

pp.：  206 – 224

List of Contributors

pp.：  224 – 228

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