Evolutionary Approaches to Protein Design ( Volume 55 )

Publication series ：Volume 55

Author： Arnold   Frances H.  

Publisher： Elsevier Science‎

Publication year： 2000

E-ISBN: 9780080493374

P-ISBN(Paperback): 9780120342556

P-ISBN(Hardback):  9780120342556

Subject： Q51 Protein

Language： ENG

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Description

This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution.

Chapter

Front Cover

pp.：  1 – 4

Evolutionary Protein Design

pp.：  4 – 5

Copyright Page

pp.：  5 – 6

CONTENTS

pp.：  6 – 10

PREFACE

pp.：  10 – 14

Chapter 1. New Functions from Old Scaffolds: How Nature Reengineers Enzymes for New Functions

pp.：  14 – 42

Chapter 2. Evolution of Protein Functon by Domain Swapping

pp.：  42 – 92

Chapter 3. Rational Evolutionary Design: The Theory of In Vitro Protein Evolution

pp.：  92 – 174

Chapter 4. Temperature Adaptation of Enzymes: Lessons from Laboratory Evolution

pp.：  174 – 240

Chapter 5. Structural Analysis of Affinity Matured Antibodies and Laboratory-Evolved Enzymes

pp.：  240 – 274

Chapter 6. Molecular Breeding: The Natural Approach to Protein Design

pp.：  274 – 306

Chapter 7. Analysis of Large Libraries of Protein Mutants Using Flow Cytometry

pp.：  306 – 330

Chapter 8. From Catalytic Asymmetric Synthesis to the Transcriptional Regulation of Genes: In Vivo and In Vitro Evolution of Proteins

pp.：  330 – 380

Chapter 9. In Vitro Selection and Evolution of Proteins

pp.：  380 – 418

AUTHOR INDEX

pp.：  418 – 442

SUBJECT INDEX

pp.：  442 – 452

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