Antigenic Variation

Author： Craig   Alister G.;Scherf   Artur  

Publisher： Elsevier Science‎

Publication year： 2003

E-ISBN: 9780080475882

P-ISBN(Paperback): 9780121948511

P-ISBN(Hardback):  9780121948511

Subject： Q93 Microbiology;R392 medical immunology;R512.91 AIDS Acquired immune deficiency syndrome (AIDS)

Language： ENG

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Description

The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.
The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.

Comprehensive coverage of antigenic variation from viruses to parasites
Discussions devoted to molecular mechanisms of host evasion
Detailed descriptions of host/pathogen interactions

Chapter

Contents

pp.：  6 – 8

Contributors

pp.：  8 – 12

Foreword

pp.：  12 – 16

Preface

pp.：  16 – 18

1 Mechanisms of Antigenic Variation: an Overview

pp.：  18 – 33

2 HIV Variation - a Question of Signal-to-Noise

pp.：  33 – 50

3 Calicivirus

pp.：  50 – 69

4 Influenza - the Chameleon Virus

pp.：  69 – 101

5 Rotavirus

pp.：  101 – 119

6 Haemophilus i nfluenzae

pp.：  119 – 139

7 Phase Variation in Helicobacter Pylori l ipopolysaccaride

pp.：  139 – 182

9 Candida albicans

pp.：  182 – 219

10 The MSG Gene Family and Antigenic Variation in the Fucus Pneumocystis carinii

pp.：  219 – 241

11 Trypanosome Antigenic Variation - a Heavy Investment in the Evasion of Immunity

pp.：  241 – 260

12 Antigenic Variation in Anaplasma marginale and Ehrlichia (Cowdria) ruminatium

pp.：  260 – 290

13 Antigenic Variation and its Significance to Babesia

pp.：  290 – 308

14 Antigenic Variation in Plasmodium falciparum and Other Plasmodium Species

pp.：  308 – 336

15 Antigenic Variation in Borrelia: Relapsing Fever and Lyme Borreliosis

pp.：  336 – 374

16 Surface Antigenic Variation in Giardia lamblia

pp.：  374 – 392

17 Free-living and Parasitic Ciliates

pp.：  392 – 420

18 The Impact of Antigenic Variation on Pathogen Population Structure, Fitness and Dynamics

pp.：  420 – 450

Index

pp.：  450 – 462

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