The Mouse in Biomedical Research ：Immunology ( 2 )

Publication subTitle ：Immunology

Publication series ：2

Author： Fox   James G.;Barthold   Stephen;Davisson   Muriel  

Publisher： Elsevier Science‎

Publication year： 2006

E-ISBN: 9780080469089

P-ISBN(Paperback): 9780123694584

P-ISBN(Hardback):  9780123694584

Subject： R-332 Medical Experiments Zoology

Language： ENG

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Description

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Chapter

Front Cover

pp.：  1 – 4

The Mouse in Biomedical Research: Immunology

pp.：  4 – 5

Copyright Page

pp.：  5 – 6

Table of Contents

pp.：  6 – 11

List of Reviewers

pp.：  11 – 12

List of Contributors

pp.：  12 – 14

Foreword

pp.：  14 – 16

Preface

pp.：  16 – 18

Overview

pp.：  18 – 74

Chapter 1. The Molecular Basis of Lymphoid Architecture in the Mouse

pp.：  74 – 126

Chapter 2. The Biology of Toll-Like Receptors in Mice

pp.：  126 – 136

Chapter 3. Genomic Organization of the Mouse Major Histocompatibility Complex

pp.：  136 – 152

Chapter 4. Some Biological Features of Dendritic Cells in the Mouse

pp.：  152 – 172

Chapter 5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes

pp.：  172 – 186

Chapter 6. Mouse Natural Killer Cells: Function and Activation

pp.：  186 – 196

Chapter 7. Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System

pp.：  196 – 212

Chapter 8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse

pp.：  212 – 224

Chapter 9. Mouse Models of Negative Selection

pp.：  224 – 240

Chapter 10. Peripheral Tolerance of T Cells in the Mouse

pp.：  240 – 260

Chapter 11. The Genetics of Mouse Models of Systemic Lupus

pp.：  260 – 278

Chapter 12. Inhibitory Receptors and Autoimmunity in the Mouse

pp.：  278 – 292

Chapter 13. Mouse Models of Immunodeficiency

pp.：  292 – 308

Chapter 14. Mouse Models to Study the Pathogenesis of Allergic Asthma

pp.：  308 – 320

Chapter 15. The Mouse Trap: How Well Do Mice Model Human Immunology?

pp.：  320 – 330

Index

pp.：  330 – 392

Colour Plates

pp.：  392 – 396

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