Description
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy.
Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments.
Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.
- The first comprehensive description of animal models of epilepsy since the early 1970's
- C
Chapter
CHAPTER 3: Cell Culture Models for Studying Epilepsy
pp.：
41 – 53
CHAPTER 4: An Overview of In Vitro Seizure Models in Acute and Organotypic Slices
pp.：
53 – 63
CHAPTER 5: The Use of Brain Slice Cultures for the Study of Epilepsy
pp.：
63 – 77
CHAPTER 6: Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research
pp.：
77 – 91
CHAPTER 7: Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures
pp.：
91 – 107
CHAPTER 8: Studying Epilepsy in the Human Brain In Vitro
pp.：
107 – 121
CHAPTER 9: In Vitro Isolated Guinea Pig Brain
pp.：
121 – 129
CHAPTER 10: Pharmacologic Models of Generalized Absence Seizures in Rodents
pp.：
129 – 145
CHAPTER 11: Models of Chemically-Induced Acute Seizures
pp.：
145 – 171
CHAPTER 12: Electrical Stimulation-Induced Models of Seizures
pp.：
171 – 179
CHAPTER 13: Alcohol Withdrawal Seizures
pp.：
179 – 197
CHAPTER 14: Alumina Gel Injection Models of Epilepsy in Monkeys
pp.：
197 – 207
CHAPTER 15: Modeling Epilepsy and Seizures in Developing Zebrafish Larvae
pp.：
207 – 217
CHAPTER 16: Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice
pp.：
217 – 241
CHAPTER 17: Spontaneous Epileptic Mutations in the Mouse
pp.：
241 – 251
CHAPTER 18: Genetic Models of Absence Epilepsy in the Rat
pp.：
251 – 267
CHAPTER 19: Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology
pp.：
267 – 279
CHAPTER 20: Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibil
pp.：
279 – 291
CHAPTER 21: Inherited Epilepsy in Mongolian Gerbils
pp.：
291 – 313
CHAPTER 22: The Cortical Freeze Lesion Model
pp.：
313 – 323
CHAPTER 23: MAM and Other “Lesion” Models of Developmental Epilepsy
pp.：
323 – 333
CHAPTER 24: In Utero Irradiation as a Model of Cortical Dysplasia
pp.：
333 – 341
CHAPTER 25: Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period
pp.：
341 – 351
CHAPTER 26: Complex Febrile Seizures—An Experimental Model in Immature Rodents
pp.：
351 – 359
CHAPTER 27: Repetitive Seizures in the Immature Brain*
pp.：
359 – 369
CHAPTER 28: The Kindling Phenomenon
pp.：
369 – 383
CHAPTER 29: Kindling Kittens and Cats
pp.：
383 – 389
CHAPTER 30: Electrical Kindling in Developing Rats
pp.：
389 – 397
CHAPTER 31: Chemical Kindling
pp.：
397 – 413
CHAPTER 32: Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a Model
pp.：
413 – 425
CHAPTER 33: Tetanus Toxin Model of Focal Epilepsy
pp.：
425 – 433
CHAPTER 34: Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy
pp.：
433 – 451
CHAPTER 35: The Pilocarpine Model of Seizures
pp.：
451 – 467
CHAPTER 36: Status Epilepticus: Electrical Stimulation Models
pp.：
467 – 483
CHAPTER 37: Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats
pp.：
483 – 495
CHAPTER 38: Chronic Partial Cortical Isolation
pp.：
495 – 513
CHAPTER 39: Head Trauma: Hemorrhage-Iron Deposition
pp.：
513 – 519
CHAPTER 40: Stroke
pp.：
519 – 539
CHAPTER 41: Models Available for Infection-Induced Seizures
pp.：
539 – 545
CHAPTER 42: Brain Tumor and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model
pp.：
545 – 553
CHAPTER 43: An Animal Model of Rasmussen’s Encephalitis
pp.：
553 – 557
CHAPTER 44: Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs
pp.：
557 – 569
CHAPTER 45: Animal Models of Drug-Refractory Epilepsy
pp.：
569 – 587
CHAPTER 46: Monitoring for Seizures in Rodents
pp.：
587 – 601
CHAPTER 47: Imaging Approaches in Small Animal Models
pp.：
601 – 619
CHAPTER 48: Behavioral Characterization of Seizures in Rats
pp.：
619 – 631
CHAPTER 49: Behavioral and Cognitive Testing Procedures in Animal Models of Epilepsy
pp.：
631 – 647
CHAPTER 50: Morphologic Approaches to the Characterization of Epilepsy Models
pp.：
647 – 671
CHAPTER 51: Animal Model Development Based on the Human Epilepsies: Which Causes and Syndromes Should Be Modeled?
pp.：
671 – 677
CHAPTER 52: What Good Are Animal Models?
pp.：
677 – 687
Models of Seizures and Epilepsy
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