Emerging Technologies in Protein and Genomic Material Analysis ( Volume 68 )

Publication series :Volume 68

Author: Marko-Varga   Gyorgy;Oroszlan   Peter  

Publisher: Elsevier Science‎

Publication year: 2003

E-ISBN: 9780080530840

P-ISBN(Paperback): 9780444509642

P-ISBN(Hardback):  9780444509642

Subject: O65 Analytical Chemistry;TB3 Engineering Materials

Language: ENG

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Description

It is widely recognized that analytical technologies and techniques are playing a pioneering role in a range of today's foremost challenging scientific endeavours, including especially biological and biomedical research. Worthy of mention, for example, are the role that high performance separation techniques played in mapping the human genome and the pioneering work done within mass spectrometry.

It is also apparent that state-of-the-art pharmaceutical and biomedical research is the major driving force of the development of new analytical techniques. Advancements in genomics research has provided the opportunity for a call for new drug targets for new technologies, which has speeded up drug discovery and helped to counteract the trend towards inflation of R&D costs.

This book has been designed to be a reference covering a wide range of protein and genomic material analysis techniques. Emerging developments are presented with applications where relevant, and biological examples are included. It was developed to meet the ever growing need for a comprehensive and balanced text on an analytical technique which has generated a tremendous amount of interest in recent years.

In addition, this book also serves as a modern textbook for advanced undergraduate and graduate courses in various disciplines including chemistry, biology and pharmacy.

Authors of the individual chapters are recognized champions of their individual research disciplines and also repr

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 14

Preface

pp.:  8 – 10

List of Contributors

pp.:  10 – 20

Contents

pp.:  14 – 8

Chapter 1. Enabling Bio-analytical Technologies for Protein and Genomic Material Analysis and their Impact on Biology

pp.:  20 – 30

Chapter 2. DNA Sequencing: From Capillaries to Microchips

pp.:  30 – 40

Chapter 3. Phosphoprotein and Phosphoproteome Analysis by Mass Spectrometry

pp.:  40 – 58

Chapter 4. Quantitative Peptide Determination Using Column-Switching Capillary Chromatography Interfaced with Mass Spectrometry

pp.:  58 – 94

Chapter 5. On-line Continuous-flow Multi-protein Biochemical Assays for the Characterization of Bio-active Compounds Using Electrospray Quadrupole Time-of-Flight Mass Spectrometry

pp.:  94 – 114

Chapter 6. Capillary Isoelectric Focusing Developments in Protein Analysis

pp.:  114 – 154

Chapter 7. Bio-affinity Extraction for the Analysis of Cytokines and Proteomics Samples

pp.:  154 – 174

Chapter 8. Peptidomics-based Discovery of Endogenous Neuropeptides in the Brain

pp.:  174 – 188

Chapter 9. The Beauty of Silicon Micromachined Microstructures Interfaced to MALDI-TOF Mass Spectrometry

pp.:  188 – 218

Chapter 10. Identification and Characterization of Peptides and Proteins Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

pp.:  218 – 260

Chapter 11. Biological Single Molecule Applications and Advanced Biosensing

pp.:  260 – 284

Subject Index

pp.:  284 – 294

Journal of Chromatography Library

pp.:  294 – 296

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