Author： Linder Patrick
Publisher： Oxford University Press
ISSN： 1362-4962
Source： Nucleic Acids Research, Vol.34, Iss.15, 2006-09, pp. : 4168-4180
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
DEAD-box proteins are characterized by nine conserved motifs. According to these criteria, several hundreds of these proteins can be identified in databases. Many different DEAD-box proteins can be found in eukaryotes, whereas prokaryotes have small numbers of different DEAD-box proteins. DEAD-box proteins play important roles in RNA metabolism, and they are very specific and cannot mutually be replaced. In vitro, many DEAD-box proteins have been shown to have RNA-dependent ATPase and ATP-dependent RNA helicase activities. From the genetic and biochemical data obtained mainly in yeast, it has become clear that these proteins play important roles in remodeling RNP complexes in a temporally controlled fashion. Here, I shall give a general overview of the DEAD-box protein family.
Related content
Access to resources
Recommend
DEAD-box RNA helicases in Escherichia coli
Nucleic Acids Research, Vol. 34, Iss. 15, 2006-09 ,pp. :