Five-year decline in estimated glomerular filtration rate associated with a higher risk of renal disease and atherosclerotic vascular disease clinical events in elderly women

Author： Lim W.H.

Publisher： Oxford University Press

ISSN： 1460-2393

Source： QJM: An International Journal of Medicine, Vol.106, Iss.5, 2013-05, pp. : 443-450

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Abstract

Background: Estimated glomerular filtration rate (eGFR) has been demonstrated to predict atherosclerotic vascular disease (ASVD)-associated clinical events independent of traditional vascular risk factors. Recent studies have demonstrated that eGFR decline over time may improve prediction of ASVD-associated mortality risk in chronic kidney disease (CKD) patients.Aim: The aim of this study is to evaluate the association between 5-year change in eGFR with renal disease and ASVD-associated clinical events.Design: Prospective observational study.Methods: A total of 1012 women over the age of 70 years from the Calcium Intake Fracture Outcome Study were included. Baseline characteristics including baseline and 5-year creatinine, participants comorbidities and complete verified 10-year records for ASVD and renal disease-associated hospitalization and/or mortality were obtained using the Western Australian Data Linkage System.Results: Participants were stratified according to annual rate of eGFR change in quartiles [1.2 (first quartile), >1.2 to 0.1 (second quartile), >0.11.7 (third quartile) and >1.7 ml/min/1.73 m²/year (fourth quartile)]. In the adjusted model, compared with participants in the fourth quartile, those in the first and/or second quartiles of annual eGFR change had significantly higher risk of renal disease and/or ASVD-associated clinical events. However, the association with renal clinical events was more pparent in participants with baseline eGFR of <60 ml/min/1.73 m².Conclusion: The results of this study suggest that the inclusion of long-term eGFR change over time might augment prognostication for renal disease and ASVD-associated clinical events in elderly women.