Author: Zhang Jun Zhang LingLi Shen Lei Xu Xi-Ming Yu HongGang
Publisher: Spandidos Publications
ISSN: 1792-1074
Source: Oncology Letters, Vol.5, Iss.3, 2013-03, pp. : 756-760
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The use of chemotherapy drugs for the treatment of cancer is an effective therapeutic measure. However, chemoresistance affects the effectiveness of the treatment. AKT overexpression has been observed in chemoresistance. AKT expression in colon cells induced cisplatin resistance. The present study demonstrated the role of reactive oxygen species (ROS) in the induction of AKT regulation by cisplatin through the activation of JAK2/STAT3 at the transcriptional level in colon cancer cells. HCT116 cells treated with cisplatin exhibited increased JAK2 and STAT3 activities. Reducing the expression of JAK2 in colon cancer cells using small interfering RNA (siRNA) decreased AKT expression. The present study demonstrated that AKT activation is closely associated with chemoresistance in human tumors. The inhibition of ROS decreased the levels of AKT in colon cancer cell lines. The JAK2/STAT3 pathway was also shown to mediate AKT expression and represents a potential target for overcoming cisplatin resistance in human tumors.
Related content
Regulation of gene expression by serine/threonine protein phosphatases
Seminars in Cancer Biology, Vol. 6, Iss. 4, 1995-04 ,pp. :
By Higashiyama M. Miyoshi Y. Kodama K. Yokouchi H. Takami K. Nishijima M. Nakayama T. Kobayashi H. Minamigawa K. Nakamura Y.
European Journal of Cancer, Vol. 36, Iss. 4, 2000-03 ,pp. :