Author： Valentinis B. Baserga R.
Publisher： Elsevier
ISSN： 0006-291X
Source： Biochemical and Biophysical Research Communications, Vol.224, Iss.2, 1996-07, pp. : 362-368
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Abstract
High concentrations of fetal bovine serum (FBS) induce apoptosis of cells in culture. A decrease in the number of insulin-like growth factor I receptors (IGF-IR) sensitizes the cells to serum-induced apoptosis. Autophosphorylation of the IGF-IR is not affected by high serum. These results may explain why the targeting of the IGF-IR renders tumor cells much more sensitive to apoptosis in vivo than in vitro.
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