Author： Bleyer Anthony J M. Balwit James
Publisher： Future Medicine
ISSN： 1475-0708
Source： Therapy, Vol.2, Iss.6, 2005-11, pp. : 823-834
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Abstract
Sevelamer hydrochloride is a nonabsorbed, calcium- and metal-free phosphate binder, used to bind phosphate and prevent phosphate accumulation in patients with kidney failure. Sevelamer hydrochloride has been an important alternative to calcium-based phosphate binders, because calcium-based binders result in increased gastrointestinal calcium absorption and a positive calcium burden in dialysis patients. Recent studies have shown that sevelamer hydrochloride slows the progression of cardiovascular calcification when compared with calcium-based binders –– such decreases in cardiovascular calcification may potentially lead to a reduction in morbidity and mortality in dialysis patients.
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