Efficacy and safety of manidipine in patients with hypertension aged 70 years or older

Author: Cristóófol Alluéé Ramóón   Manzanares Brotons Francesc  

Publisher: Future Medicine

ISSN: 1745-509X

Source: Aging Health, Vol.7, Iss.4, 2011-08, pp. : 521-528

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Abstract

This study aimed to assess the efficacy and safety of manidipine in patients with hypertension aged 70 years or older. For this purpose, a 6-month study was performed. A total of 48 patients (mean age: 80.5 ±± 7.1 years; 33.3% male) were included. The most common comorbidity was diabetes (39.6%). Manidipine 10 mg/day was prescribed in 72.9% of the patients and manidipine 20 mg/day in 27.1% of patients. Treatment with manidipine was associated with a significant decrease of blood pressure, from 163.3 ±± 12.7/88.8 ±± 9.6 mmHg to 147.8 ±± 10.0/80.3 ±± 6.4 mmHg (p < 0.01). Microalbuminuria was reduced from 27.1 to 8.3% during the study (p = 0.004). Barthel index and Get Up and Go test results remained unchanged, whilst there was a not significant improvement in the results from the Pfeiffer’’s test. Manidipine administration was safe (only one patient left the study) and effective since blood pressure decreased significantly in a poorly controlled group of hypertensive patients (89% aged over 75 years and 58% aged over 80 years).

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