Comparison of Three Triple Regimens with Omeprazole or Ranitidine Bismuth Citrate for Helicobacter pylori Eradication

Author: Farup P. G.   Tholfsen J.   Wetternus S.   Torp R.   Høie O.   Lange O. J.  

Publisher: Informa Healthcare

ISSN: 0036-5521

Source: Scandinavian Journal of Gastroenterology, Vol.37, Iss.12, 2002-12, pp. : 1374-1379

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Abstract

Background: Regimens with ranitidine bismuth citrate (RBC) or omeprazole (O) are effective in eradicating Helicobacter pylori. This randomized, open, multicentre trial compares three different regimens with these drugs. Methods: Consecutive H. pylori +ve outpatients were included. The alternative regimens were: 1) O 20 mg, clarithromycin (C) 250 mg and metronidazole (M) 500 mg (O·C·M), 2) RBC 400 mg, C 250 mg and M 500 mg (RBC·C·M), 3) RBC 400 mg, tetracycline (T) 1000 mg and M 500 mg [RBC·T·M]. All drugs were given twice daily for 7 days. H. pylori infection was assessed with H. pylori urea breath tests. Results: 426 H. pylori +ve patients were included (mean age 58 years [range 18-88], male/female: 244/182). The eradication rates (intention to treat) in the O·C·M, RBC·C·M and RBC·T·M groups were 117/137 (85%), 141/146 (97%) and 117/143 (82%), respectively (P < 0.001, overall assessment). There were no significant differences in side effects between the alternatives. Conclusion: In this trial, RBC·C·M was the most effective one, it was well tolerated and compliance was satisfactory. RBC·T·M is an alternative to regimens with clarithromycin.

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