Author： Ishikawa Tomoaki Hokama Hideyuki Katagiri Yoshiaki Goto Hiroshi Usui Masahiko
Publisher： Informa Healthcare
ISSN： 0271-3683
Source： Current Eye Research, Vol.30, Iss.2, 2005-02, pp. : 93-101
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Abstract
Purpose : To examine the immunosuppressive and neuroprotective effects of intravitreal injection of tacrolimus in experimental uveitis. Methods : Tacrolimus (40 µ g) was injected intravitreally in rabbits to examine safety. Experimental uveitis was induced in rabbits by systemic immunization with bovine serum albumin (BSA) followed by intravitreal challenge with BSA. On day 1 after BSA challenge, tacrolimus (20 or 40 µ g) or betamethasone (400 µ g) was injected intravitreally in one eye and balanced salt solution in the contralateral eye. The eyes were evaluated by slit-lamp biomicroscopy, electroretinography, and histopathology. Results : No local or systemic adverse reaction was observed in normal rabbits. In experimental uveitis, intravitreal injection of tacrolimus significantly reduced intraocular inflammation in histopathological analysis ( p
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