Author: de Martin Paula E. Novick Peter Ferro-Novick Susan
Publisher: NRC Research Press
ISSN: 1208-6002
Source: Biochemistry and Cell Biology, Vol.83, Iss.6, 2005-12, pp. : 752-761
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The endoplasmic reticulum (ER) is a fundamental organelle required for protein assembly, lipid biosynthesis, and vesicular traffic (McMaster 2001; Staehelin 1997; Voeltz et al. 2002), as well as calcium storage and the controlled release of calcium from the ER lumen into the cytosol (Johnson and van Waes 1999; Ma and Hendershot 2002; Matlack et al. 1998; Meldolesi and Pozzan 1998). Membranes functionally linked to the ER by vesicle-mediated transport, such as the Golgi complex, endosomes, vacuoles-lysosomes, secretory vesicles, and the plasma membrane, originate largely from proteins and lipids synthesized in the ER (Voeltz et al. 2002). In this review we will discuss the structural organization of the ER and its inheritance.
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