Effects of 6 Months Exercise Training on Ventricular Remodelling and Autonomic Tone in Patients with Acute Myocardial Infarction and Percutaneous Coronary Intervention

Author： Zheng Huan Luo Ming Shen Yi Ma Yuan Kang Wenhui

Publisher： Medical Journals Limited

ISSN： 1650-1977

Source： Journal of Rehabilitation Medicine, Vol.40, Iss.9, 2008-10, pp. : 776-779

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Abstract

Objective: To study the effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention.Design: Single-blinded randomized control trial.Participants: Sixty patients with acute myocardial infarction who had undergone percutaneous coronary intervention.Methods: The exercise group followed a 6-month supervised exercise programme, while the control group received routine recommendations. All patients underwent an incremental cardiopulmonary exercise test and Doppler echocardiography at baseline and after 6 months.Results: three patients in the exercise group did not complete the programme. At 6 months follow-up, an improvement was seen in the exercise group compared with the control group regarding peak VO₂ (p<0.01), Powermax (p<0.05), VO₂ at anaerobic threshold (p<0.01), time to reach anaerobic threshold (p<0.05), heart rate recovery (p<0.01), left ventricular end-diastolic diameter (p<0.01) and left ventricular ejection fraction (p<0.05).Conclusion: Six months exercise training in patients with acute myocardial infarction and percutaneous coronary intervention with mild ventricular systolic dysfunction could prevent ventricular remodelling to a certain extent, and favourable modulating sympatho-vagal balance may be an important mechanism.