Comparative Sensitivity of Cholinesterases of Different Origin to Some Irreversible Inhibitors

Author: Moralev S. N.   Rozengart E. V.  

Publisher: MAIK Nauka/Interperiodica

ISSN: 0022-0930

Source: Journal of Evolutionary Biochemistry and Physiology, Vol.40, Iss.1, 2004-01, pp. : 1-17

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Abstract

The analytical review is presented of literature data obtained with use of different substrates, on sensitivity of more than 90 preparations of cholinesterases from 65 different animals (vertebrate, insects, molluscs) to the most studied 6 irreversible inhibitors (eserine and 5 organophosphorus compounds). The considered data are discussed from the point of view of comparative biochemistry and in the light of current information about structure of active center of cholinesterases.

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