Author： Morukov B. Rykova M. Antropova E. Berendeeva T. Ponomaryov S. Larina I.
Publisher： MAIK Nauka/Interperiodica
ISSN： 0362-1197
Source： Human Physiology, Vol.36, Iss.3, 2010-05, pp. : 264-273
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Abstract
The results of the study of the innate and adaptive immunity indicators in 12 cosmonauts who took part in long-term (128–215 days) expeditions on board the International Space Station (ISS) are presented. It was shown that the space flight may lead to deviations in the human immune system. A decrease in the functional activity of phagocytes, NK and T-cells, as well as in the ability of immunocompetent cells to synthesize cytokines were observed. Significant individual changes were observed in the immune system’s response to a long-term space flight, which indicated an individual’s predisposition to the development of immune reactivity disorders under varying gravitation conditions.
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