Quantitative chromatographic analysis under changes in the composition of samples in the course of sample preparation: A modification of the double internal standard method

Author： Zenkevich I. Makarov E. Makarova I.

Publisher： MAIK Nauka/Interperiodica

ISSN： 1061-9348

Source： Journal of Analytical Chemistry, Vol.62, Iss.8, 2007-08, pp. : 748-755

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Abstract

A well-known method of quantitative chromatographic analysis—the double internal standard method—is modified. This modification consists in the use of two analyte homologs (preceding and following ones) as standard substances. This approach can be used to compensate for considerable losses of both test components and standard substances in the course of various sample preparation procedures. The advantages of this method are illustrated using liquid extraction, vapor-phase analysis, distillation of volatile components with volatile solvents (preconcentration in a condensate), and evaporation of volatile solvents (preconcentration in a distillation residue) as examples. The method proposed maintains a high precision of determinations (the relative error (c _specified − c _found)/c _specified is 1–6%).