Use of nanoparticles in the electrochemical analysis of biological samples

Author: Vertelov G.   Olenin A.   Lisichkin G.  

Publisher: MAIK Nauka/Interperiodica

ISSN: 1061-9348

Source: Journal of Analytical Chemistry, Vol.62, Iss.9, 2007-09, pp. : 813-824

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Abstract

The specific effects of various nanoparticles on processes occurring in the electrochemical analysis of biological samples are considered. The material classification is based on a structural principle of the organization of a sensing element. Nanoparticles can occur immediately on its surface or in the bulk of an analyte (in the latter case, they can be chemically bound to the surface); they can be incorporated into the analyte and serve as its labels. The use of nanoparticles significantly extends the capabilities of bioelectrochemical methods of analysis. In a number of cases, the use of nanoparticles provides an opportunity to abandon the use of enzymes; this is very promising for clinical analysis. Methods for the electrochemical analysis of biological samples with the use of nanoparticles can be a serious addition to classical biochemical methods.

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