A mechanochemical theory for the ATP-fuelled biomolecular motors

Author: Liu Ming S.   Todd B.D.   Sadus Richard J.  

Publisher: Inderscience Publishers

ISSN: 1475-7435

Source: International Journal of Nanotechnology, Vol.6, Iss.12, 2009-09, pp. : 1121-1130

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Abstract

Biomolecular motors are normally single or complex biomolecules exerting mechanical forces over molecular and cellular scales. The ATP-fuelled biomolecular motors can transduce the chemical energy from ATP hydrolysis into forces and motions in cells. In biomolecular motors, transport reactions are both stoichiometric and enzymatic. We outline a mechanochemical theoretical framework for biomolecular motors to understand their enzymatic kinetics and continuous dynamics. The theory is validated by describing the operating mechanism and dynamics of several ATP-fuelled molecular motors driving various loads.