Author: Andersen E S Muren L P Sørensen T S Noe K Ø Thor M Petersen J B Høyer M Bentzen L Tanderup K
Publisher: IOP Publishing
ISSN: 0031-9155
Source: Physics in Medicine and Biology, Vol.57, Iss.21, 2012-11, pp. : 7089-7100
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Abstract
Variations in bladder position, shape and volume cause uncertainties in the doses delivered to this organ during a course of radiotherapy for pelvic tumors. The purpose of this study was to evaluate the potential of dose accumulation based on repeat imaging and deformable image registration (DIR) to improve the accuracy of bladder dose assessment. For each of nine prostate cancer patients, the initial treatment plan was re-calculated on eight to nine repeat computed tomography (CT) scans. The planned bladder dose–volume histogram (DVH) parameters were compared to corresponding parameters derived from DIR-based accumulations as well as DVH summation based on dose re-calculations. It was found that the deviations between the DIR-based accumulations and the planned treatment were substantial and ranged (−0.5–2.3) Gy and (−9.4–13.5) Gy for
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