Author： Kovalev I. V. Baskakov M. B. Anfinogenova Ya. D. Borodin Yu. L. Kilin A. A. Minochenko I. L. Popov A. G. Kapilevich L. V. Medvedev M. A. Orlov S. N.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.136, Iss.2, 2003-08, pp. : 145-149
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Abstract
The effect of Na+,K+,2Cl- cotransport inhibitor bumetanide on action potentials and contractions of smooth muscle cells in the ureter of guinea pigs evoked by electrical stimulation was studied by the method of double sucrose bridge. Bumetanide (10-100 μM) dose-dependently suppressed action potential and contractions of smooth muscle cells induced by 1-10 μM histamine, 10 μM mesatone, 5 mM tetraethylammonium, and 100 μM sodium nitroprusside. Our findings suggest that test substances modulate Na+,K+,2Cl- cotransport in smooth muscle cells.
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