In Vitro Effects of Pentifin on Some Neurotransmitter Systems in the Brain

Author: Gorbatova E. N.   Dagaev S. G.   Dolgo-Saburov V. B.   Dukhovich F. S.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.136, Iss.2, 2003-08, pp. : 174-175

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Abstract

Pentifin and dopamine D1 receptor antagonist SCH-23390 possess similar pharmacological properties. In the present work we studied In Vitro effects of Pentifin on dopamine receptors. Experiments on rat ductus deferents showed that Pentifin acts as a weak ligand of dopamine receptors. Our results indicate that the antihaloperidol effect of Pentifin is not related to the blockade of dopamine receptors.