Effect of β-Adrenoceptor Blockade on Cardiac Activity in Rats during Postnatal Ontogeny

Author: Anikina T. A.   Bilalova G. A.   Sitdikov F. G.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.136, Iss.3, 2003-09, pp. : 231-234

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Abstract

Electrical stimulation of the right stellate ganglion produces a positive chronotropic effect in 21-, 56-, and 100-day-old rats. The response of the heart rate to suprathreshold stimulation increased from the 21st to 100th day. By contrast, during β-adrenoceptor blockade the heart rate response decreased. The data suggest that the role of β-adrenoceptor in the regulation of cardiac chronotropic function increased with age.

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