Relationship between High Sensitivity of Suckling Mice to Hepatocarcinogenic and Antiglucocorticoid Effects of o-Aminoazotoluene and Diethylnitrosamine

Author: Il'nitskaya S. I.   Vasileva E. D.   Kropachev K. Yu.   Kaledin V. I.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.137, Iss.6, 2004-06, pp. : 548-550

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Suckling mice were more sensitive to the hepatocarcinogenic effect of various carcinogens compared to adult animals. After treatment with o-aminoazotoluene and diethylnitrosamine HNF3-DNA-binding capacity and glucocorticoid-induced liver tyrosine aminotransferase activity in suckling mice decreased more significantly than in adult animals.