NO-Dependent Mechanism of Adrenergic Reaction of Systemic Hemodynamics

Author: Osadchii L.   Balueva T.   Sergeev I.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.140, Iss.2, 2005-08, pp. : 159-161

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Abstract

Blockade of NO synthesis in narcotized rats potentiated pressor effects of phenylephrine by 55% and increased total peripheral resistance by 153%. Vasodilation caused by enhanced NO secretion modulated pressor shifts evoked by stimulation of α1-adrenoceptors with phenylephrine.