

Author: Tverdokhlebov A. Lyashenko A. Volovenko Yu. Tolmachev A.
Publisher: Springer Publishing Company
ISSN: 0009-3122
Source: Chemistry of Heterocyclic Compounds, Vol.40, Iss.12, 2004-12, pp. : 1536-1542
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Abstract
2-Hetaryl-3-oxo-4-phthalimidobutyronitriles (and pentanonitriles) were obtained with high yields by C-acylation of hetarylacetonitriles with N-phthaloylglycine and α-alanine chlorides respectively under the conditions of base catalysis. Hydrazinolysis of the phthaloyl protection in these compounds leads to the formation of 5-amino-4-hetaryl-2,3-dihydro-1H-3-pyrrolones.
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