Investigation of naphthyridines. 16. Synthesis of derivatives of 2,5-dioxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acids from anilides (hydrazides) of 6-oxo-2-styrylnicotinic acids

Author: Deyanov A.   Konshin M.   Semenova Z.  

Publisher: Springer Publishing Company

ISSN: 0009-3122

Source: Chemistry of Heterocyclic Compounds, Vol.40, Iss.12, 2004-12, pp. : 1560-1563

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Abstract

Heating anilides (hydrazides) of 5-cyano-6-oxo-2-styrylnicotinic acids in polyphosphoric acid (PPA) leads to amides of 7-aryl-2,5-dioxo-6-phenyl(amino)-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acids, which on heating with perchloric acid in acetic acid give the corresponding acids.