Conserved (CT)n·(GA)n Repeats in the Non-coding Regions at the Gpdh Locus are Binding Sites for the GAGA Factor in Drosophila melanogaster and its Sibling Species

Author： Tchoubrieva E.B.   Gibson J.B.  

Publisher： Springer Publishing Company

ISSN： 0016-6707

Source： Genetica, Vol.121, Iss.1, 2004-05, pp. : 55-63

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Abstract

The (CT)n·(GA)n rich sequences in the upstream and 5′ intron enhancer regions of the sn-glycerol-3-phosphate dehydrogenase (Gpdh) gene in Drosophila melanogaster, its sibling and distantly related species are conserved in their position and in the number of repeats. Using in vitro DNA-footprint analyses we show that the GAGA factor binds to these multiple closely spaced and overlapping conserved (CT)n·(GA)n repeats in D. melanogaster and D. erecta.

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