Author: Zhu Xi-Chen Yu Jin-Tai Jiang Teng Tan Lan
Publisher: Humana Press, Inc
ISSN: 0893-7648
Source: Molecular Neurobiology, Vol.48, Iss.3, 2013-12, pp. : 702-714
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Autophagy is an essential and conserved lysosomal degradation pathway that controls the quality of cytoplasm by eliminating the intracellular aggregated proteins and damaged organelles. Autophagy works in mammalian target of rapamycin (mTOR)-dependent pathway or mTOR-independent pathway to keep the neuronal homeostasis. Mounting evidence has implicated the importance of defective autophagy in the pathogenesis of aging and neurodegenerative diseases, especially in Alzheimer’s disease (AD). It has also demonstrated a neuroprotective role of autophagy in mediating the degradation of amyloid beta and tau which are major factors of AD. Amounts of molecules function in either mTOR-dependent pathway or mTOR-independent pathway to induce autophagy, which maybe a potential treatment for AD. In this review, we summarize the latest studies concerning the role of autophagy in AD and explore autophagy modulation as a potential therapeutic strategy for AD. However, to date, little of the researches on autophagy have been performed to investigate the modulation in AD; more investigations need to be confirmed in the future.
Related content
Immunological approaches as therapy for Alzheimer’s disease
By Solomon Beka
Expert Opinion on Biological Therapy, Vol. 2, Iss. 8, 2002-12 ,pp. :
Modulating nitric oxide signaling in the CNS for Alzheimer’s disease therapy
By Zhihui Qin
Future Medicinal Chemistry, Vol. 5, Iss. 12, 2013-08 ,pp. :
Role of Autophagy in Alzheimer's Disease
Current Enzyme Inhibition, Vol. 9, Iss. 1, 2013-05 ,pp. :
Molecular basis of Alzheimer’s disease
Molecular Biology, Vol. 41, Iss. 2, 2007-04 ,pp. :