Synthesis and biological activity of o-isobornylphenol derivatives

Author: Plotnikov M.   Smol’yakova V.   Ivanov I.   Kuchin A.   Chukicheva I.   Buravlev E.   Krasnov E.  

Publisher: Springer Publishing Company

ISSN: 0091-150X

Source: Pharmaceutical Chemistry Journal, Vol.44, Iss.10, 2011-01, pp. : 530-533

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Abstract

Hemorheological and antiaggregant properties of new o-isobornylphenol derivatives were investigated in ex vivo experiments. 4-Methyl-2,6-diisobornylphenol and 2-(dibutylamino)methyl-4-methyl-6-isobornylphenol hydrochloride demonstrated the maximum hemorheological activity. After intragastric administration, these compounds decreased the blood viscosity at low shear rates, suppressed the development of blood “hyperviscosity” before incubation (20.0 ± 0.4°C, 1 h), and reduced ADP-induced (4 × 10–6 M) aggregation of platelets. The hemorheological and antiaggregant effects of the investigated compounds were comparable to those of pentoxifylline.

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